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TitleIdentification and Characterization of a Small Molecule Ligand for the Huntingtin-HAP40 Complex
Journal, issue, pagesBiorxiv, Year 2025
Publish dateOct 16, 2025 (structure data deposition date)
AuthorsBalakrishnan S / Deme J / Lea SM / Harding RJ
External linksBiorxiv / Search PubMed
MethodsEM (single particle)
Resolution2.3 Å
Structure data

73361

9yr6

EMDB-73361, PDB-9yr6:
Structure of HTTQ23-HAP40 complex bound to a small molecule ligand
Method: EM (single particle) / Resolution: 2.3 Å

Chemicals

PDB-1cyy:
CRYSTAL STRUCTURE OF THE 30 KDA FRAGMENT OF E. COLI DNA TOPOISOMERASE I. HEXAGONAL FORM

Source
  • homo sapiens (human)
KeywordsPEPTIDE BINDING PROTEIN / Huntingtin / Polyglutamine expansion / small molecule ligand / ligand discovery

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