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TitleMetal induced conformational changes in human insulin: Crystal structures of Sr+2, Ni+2 and Cu+2 complexes of human insulin
Journal, issue, pagesTo be Published
Publish dateAug 7, 2009 (structure data deposition date)
AuthorsRaghavendra, N. / Pattabhi, V. / Rajan, S.S.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.85 - 1.9 Å
Structure data

PDB-3ilg:
Crystal structure of humnan insulin Sr+2 complex
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-3inc:
Crystal structure of human insulin with Ni+2 complex
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-SR:
STRONTIUM ION

ChemComp-HOH:
WATER

ChemComp-NI:
NICKEL (II) ION

Source
  • homo sapiens (human)
KeywordsHORMONE / Insulin / conformational state / metal binding / Carbohydrate metabolism / Cleavage on pair of basic residues / Diabetes mellitus / Disease mutation / Disulfide bond / Glucose metabolism / Secreted

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