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TitleSynthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-beta-hydroxylase
Journal, issue, pagesChem Sci, Vol. 12, Page 1327-1342, Year 2021
Publish dateMay 6, 2020 (structure data deposition date)
AuthorsBrewitz, L. / Nakashima, Y. / Schofield, C.J.
External linksChem Sci / Search PubMed
MethodsX-ray diffraction
Resolution1.53 Å
Structure data

PDB-6yyx:
Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 3-methyl-2-oxoglutarate, and factor X substrate peptide fragment(39mer-4Ser)
Method: X-RAY DIFFRACTION / Resolution: 1.53 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-Q1Z:
(3~{R})-3-methyl-2-oxidanylidene-pentanedioic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Aspartyl/asparaginyl beta-hydroxylase / Dioxygenase

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