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TitleCryo-EM structures of two broadly SARS-CoV-2 neutralizing monoclonal antibodies isolated from a single individual that differ in their target specificities
Journal, issue, pagesTo Be Published
Publish dateFeb 16, 2024 (structure data deposition date)
AuthorsRencilin, C.F. / Bhattacharya, J. / Dutta, S.
External linksSearch PubMed
MethodsEM (single particle)
Resolution4.4 - 4.8 Å
Structure data

PDB-8ybs:
State - I: Spike 2-up RBD with THSC20.HVTR04 (Fab4)
Method: ELECTRON MICROSCOPY / Resolution: 4.54 Å

PDB-8yby:
State - I: Spike 2-up RBD with THSC20.HVTR26 (Fab26) - single Fab masked
Method: ELECTRON MICROSCOPY / Resolution: 4.4 Å

PDB-8ybz:
State - II: Spike 3-up RBD with THSC20.HVTR26 (Fab26)
Method: ELECTRON MICROSCOPY / Resolution: 4.8 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • severe acute respiratory syndrome coronavirus
  • homo sapiens (human)
KeywordsPROTEIN BINDING / Cryo-EM Analysis / Spike Protein / monoclonal antibody

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