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Title | Identification and optimisation of 3,3-dimethyl-azetidin-2-ones as potent and selective inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11-beta-HSD1) |
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Journal, issue, pages | TO BE PUBLISHED |
Publish date | Nov 15, 2013 (structure data deposition date) |
Authors | McCoull, W. / Augustin, M. / Blake, C. / Ertan, A. / Kilgour, E.K. / Krapp, S. / Moore, J.E. / Newcombe, N.J. / Packer, M.J. / Rees, A. ...McCoull, W. / Augustin, M. / Blake, C. / Ertan, A. / Kilgour, E.K. / Krapp, S. / Moore, J.E. / Newcombe, N.J. / Packer, M.J. / Rees, A. / Revill, J. / Scott, J.S. / Selmi, N. / Gerhardt, S. / Ogg, D.J. / Steinbacher, S. / Whittamore, P.R.O. |
External links | Search PubMed |
Methods | X-ray diffraction |
Resolution | 2.9 Å |
Structure data | PDB-4nmh: |
Chemicals | ChemComp-2KG: ChemComp-NDP: ChemComp-SO4: ChemComp-HOH: |
Source |
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Keywords | oxidoreductase/oxidoreductase INHIBITOR / NAD(P)-binding Rossmann-fold domains / OXIDOREDUCTASE / oxidoreductase-oxidoreductase INHIBITOR complex |