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TitleEngineering a Carbonyl Reductase to Simultaneously Increase Activity Toward Bulky Ketone and Isopropanol for Dynamic Kinetic Asymmetric Reduction via Enzymatic Hydrogen Transfer
Journal, issue, pagesAcs Catalysis, Vol. 13, Page 9960-9968, Year 2023
Publish dateJun 14, 2023 (structure data deposition date)
AuthorsZhang, H. / Chen, X. / Lv, T. / Li, Q. / Liu, W. / Feng, J. / Liu, X. / Yao, P. / Wu, Q. / Zhu, D.
External linksAcs Catalysis / Search PubMed
MethodsX-ray diffraction
Resolution1.4 - 1.63 Å
Structure data

PDB-8jqj:
Crystal structure of carbonyl reductase SSCR mutant 1 from Sporobolomyces Salmonicolor
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-8jqk:
Crystal structure of a carbonyl reductase SSCR mutant from Sporobolomyces Salmonicolor
Method: X-RAY DIFFRACTION / Resolution: 1.63 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • sporobolomyces salmonicolor (yeast)
KeywordsOXIDOREDUCTASE / SSCR / reductase / carbonyl reductase

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