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TitleStructure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-halogenated orotate derivatives
Journal, issue, pagesTo be Published
Publish dateNov 13, 2012 (structure data deposition date)
AuthorsInaoka, D.K. / Iida, M. / Tabuchi, T. / Lee, N. / Matsuoka, S. / Shiba, T. / Sakamoto, K. / Suzuki, S. / Balogun, E.O. / Nara, T. ...Inaoka, D.K. / Iida, M. / Tabuchi, T. / Lee, N. / Matsuoka, S. / Shiba, T. / Sakamoto, K. / Suzuki, S. / Balogun, E.O. / Nara, T. / Aoki, T. / Inoue, M. / Honma, T. / Tanaka, A. / Harada, S. / Kita, K.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.42 Å
Structure data

PDB-3w1a:
Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-halogenated orotate derivatives
Method: X-RAY DIFFRACTION / Resolution: 1.42 Å

Chemicals

ChemComp-FMN:
FLAVIN MONONUCLEOTIDE

ChemComp-NCO:
COBALT HEXAMMINE(III)

ChemComp-FOT:
5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • trypanosoma cruzi (eukaryote)
KeywordsOXIDOREDUCTASE / Rossmann Fold / Dihydroorotate/orotate binding / Cytosol

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