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TitleStabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer
Journal, issue, pagesTo Be Published
Publish dateDec 14, 2022 (structure data deposition date)
AuthorsVisser, E.J. / Donaldson Collier, M. / Siefert, J. / Konstantinidou, M. / Paul, S. / Cossar, P. / Miley, G. / Meijer, O. / Arkin, M.R. / Ottmann, C. ...Visser, E.J. / Donaldson Collier, M. / Siefert, J. / Konstantinidou, M. / Paul, S. / Cossar, P. / Miley, G. / Meijer, O. / Arkin, M.R. / Ottmann, C. / Zwart, W. / Brunsveld, L.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.46 - 1.65 Å
Structure data

PDB-8bzd:
deAc-FC stabilizer of 14-3-3 and ERalpha
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-8bzf:
FC-J acetonide stabilizer of 14-3-3 and ERalpha
Method: X-RAY DIFFRACTION / Resolution: 1.53 Å

PDB-8bzg:
FC-31 stabilizer of 14-3-3 and ERalpha
Method: X-RAY DIFFRACTION / Resolution: 1.49 Å

PDB-8bzh:
FC-NAc stabilizer of 14-3-3 and ERalpha
Method: X-RAY DIFFRACTION / Resolution: 1.46 Å

PDB-8bzt:
FC-NAg stabilizer of 14-3-3 and ERalpha
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-8c0l:
FC-THF stabilizer of 14-3-3 and ERalpha
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-SIT:
De-acetylated Fusicoccin

ChemComp-HOH:
WATER

ChemComp-SJ4:
Fusicoccin J-acetonide


ChemComp, No image

ChemComp-SJC:
Unknown entry

ChemComp-EZ5:
~{N}-[(2~{S})-2-[(1~{E},3~{R},4~{S},8~{R},9~{R},10~{R},11~{S},14~{S})-14-(methoxymethyl)-3,10-dimethyl-8-[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(2-methylbut-3-en-2-yloxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,9-bis(oxidanyl)-6-tricyclo[9.3.0.0^{3,7}]tetradeca-1,6-dienyl]propyl]ethanamide


ChemComp, No image

ChemComp-SKR:
Unknown entry

ChemComp-FC7:
Fusicoccin A-THF

Source
  • homo sapiens (human)
KeywordsSTRUCTURAL PROTEIN / 14-3-3 / stabilization / ERalpha / fusicoccin

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