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TitleDiscovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors
Journal, issue, pagesTO BE PUBLISHED
Publish dateSep 21, 2009 (structure data deposition date)
AuthorsTao, Z.F. / Hasvold, L. / Leverson, J. / Han, E. / Guan, R. / Johson, E.F. / Stoll, V.S. / Stewart, K.D. / Stamper, G. / Soni, N.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.1 - 2.8 Å
Structure data

PDB-3jxw:
Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-3jy0:
Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3jya:
Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-LXG:
8-[(E)-2-cyclopropylethenyl]-2-[(dimethylamino)methyl][1]benzothieno[3,2-d]pyrimidin-4(3H)-one

ChemComp-LYG:
8-chloro-2-{[(3S)-3-hydroxypyrrolidin-1-yl]methyl}[1]benzothieno[3,2-d]pyrimidin-4(3H)-one

ChemComp-LWG:
6,9-dichloro[1]benzothieno[3,2-d]pyrimidin-4(3H)-one

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Pim-1 / Alternative initiation / ATP-binding / Cell membrane / Cytoplasm / Kinase / Manganese / Membrane / Metal-binding / Nucleotide-binding / Nucleus / Phosphoprotein / Polymorphism / Proto-oncogene / Serine/threonine-protein kinase

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