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Structure paper

TitleActivator-Bound Structures of Human Pyruvate Kinase M2
Journal, issue, pagesto be published
Publish dateMar 24, 2009 (structure data deposition date)
AuthorsHong, B. / Dimov, S. / Tempel, W. / Auld, D. / Thomas, C. / Boxer, M. / Jianq, J.-K. / Skoumbourdis, A. / Min, S. / Southall, N. ...Hong, B. / Dimov, S. / Tempel, W. / Auld, D. / Thomas, C. / Boxer, M. / Jianq, J.-K. / Skoumbourdis, A. / Min, S. / Southall, N. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Weigelt, J. / Bochkarev, A. / Inglese, J. / Park, H.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.6 - 2 Å
Structure data

PDB-3gqy:
Activator-Bound Structure of Human Pyruvate Kinase M2
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-3gr4:
Activator-Bound Structure of Human Pyruvate Kinase M2
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-3h6o:
Activator-Bound Structure of Human Pyruvate Kinase M2
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-FBP:
1,6-di-O-phosphono-beta-D-fructofuranose

ChemComp-TLA:
L(+)-TARTARIC ACID

ChemComp-UNX:
Unknown entry

ChemComp-DZG:
1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine

ChemComp-HOH:
WATER

ChemComp-DYY:
1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-D8G:
6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / activator / Acetylation / Allosteric enzyme / Alternative splicing / Glycolysis / Kinase / Magnesium / Metal-binding / Phosphoprotein / Polymorphism / Pyruvate / Structural Genomics / Structural Genomics Consortium / SGC

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