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Structure paper

TitleActive site plasticity of endonuclease VIII: Conformational changes compensating for different substrate and mutations of critical residues
Journal, issue, pagesTo be Published
Publish dateJan 29, 2007 (structure data deposition date)
AuthorsGolan, G. / Zharkov, D.O. / Grollman, A.P. / Shoham, G.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.4 Å
Structure data

PDB-2ea0:
Crystal structure of the DNA repair enzyme endonuclease-VIII (Nei) from E. coli in complex with AP-site containing DNA substrate
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-ZN:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
KeywordsHYDROLASE/DNA / Endonuclease VIII / oxidative damage / DNA repair / base excision / covalent intermediate / reaction mechanism / HYDROLASE-DNA COMPLEX

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