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| Title | Linker-rigidified VHL homodimerizers convert degraders into stabilizers of non-ubiquitinable ternary complexes |
|---|---|
| Journal, issue, pages | Biorxiv, Year 2025 |
| Publish date | Oct 24, 2025 (structure data deposition date) |
Authors | Crowe C / Salerno A / Sathe G / Marsh G / Maple H / Ciulli A |
External links | Biorxiv / Search PubMed |
| Methods | EM (single particle) |
| Resolution | 6.9 - 7.8 Å |
| Structure data | EMDB-55480, PDB-9t32: ![]() EMDB-55558: The Cullin 2 RING VHL E3 ligase dimerized by the homoPROTAC CM11, C1 symmetry |
| Chemicals | ![]() PDB-1jtc: |
| Source |
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Keywords | LIGASE / PROTAC / homoPROTAC / dimerizer / CM11 / VHL / von Hippel-Lindau / Cullin 2 / RING / E3 / targeted protein degradation |
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