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TitleInterleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes
Journal, issue, pagesBiorxiv, Year 2020
Publish dateJun 1, 2018 (structure data deposition date)
AuthorsChamberlain, T.C. / Cheung, S.T. / Yoon, J.S.J. / Ming-Lum, A. / Gardill, B.R. / Shakibakho, S. / Dzananovic, E. / Ban, F. / Samiea, A. / Jawanda, K. ...Chamberlain, T.C. / Cheung, S.T. / Yoon, J.S.J. / Ming-Lum, A. / Gardill, B.R. / Shakibakho, S. / Dzananovic, E. / Ban, F. / Samiea, A. / Jawanda, K. / Priatel, J. / Krystal, G. / Ong, C.J. / Cherkasov, A. / Andersen, R.J. / McKenna, S.A. / Van Petegem, F. / Mui, A.L.
External linksBiorxiv / Search PubMed
MethodsX-ray diffraction
Resolution1.499 Å
Structure data

PDB-6dlg:
Crystal structure of a SHIP1 surface entropy reduction mutant
Method: X-RAY DIFFRACTION / Resolution: 1.499 Å

Chemicals

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsHYDROLASE / PI3K / PIP3 / PI-3 / 4-P2 / apoptosis / immunity

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