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TitleEnzymatic Synthesis of 3'-5', 3'-5' Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations
Journal, issue, pagesBiochemistry, Year 2021
Publish dateApr 20, 2021 (structure data deposition date)
AuthorsNovotna, B. / Hola, L. / Stas, M. / Gutten, O. / Smola, M. / Zavrel, M. / Vavrina, Z. / Budesinsky, M. / Liboska, R. / Chevrier, F. ...Novotna, B. / Hola, L. / Stas, M. / Gutten, O. / Smola, M. / Zavrel, M. / Vavrina, Z. / Budesinsky, M. / Liboska, R. / Chevrier, F. / Dobias, J. / Boura, E. / Rulisek, L. / Birkus, G.
External linksBiochemistry / Search PubMed
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-7ob3:
hSTING in complex with 3',3'-c-di-araAMP
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-V7E:
3',3'-c-di-araAMP

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / CDN / Innate Immune system / receptor

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