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Author
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IF

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Structure paper

TitleSubunit abundance shapes GABAA receptor stoichiometry
Journal, issue, pagesTo Be Published
Publish dateJun 14, 2023 (structure data deposition date)
AuthorsSente A / Malinauskas T / Naydenova K / Hardwick SW / Chirgadze DY / Aricescu AR
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.6 Å
Structure data

17636

8pet

EMDB-17636, PDB-8pet:
Cryo-EM structure of the full-length human alpha1beta3 GABA(A) receptor (babba arrangement) in complex with nanobody Nb25, expressed with a 5-fold excess of beta3 over alpha1
Method: EM (single particle) / Resolution: 2.6 Å

Chemicals

ChemComp-R16:
HEXADECANE

ChemComp-PIO:
[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate

ChemComp-D10:
DECANE

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsMEMBRANE PROTEIN / Neurotransmitter receptor / pentameric ligand-gated ion channel / Type-A GABA receptor / GABA-A receptor

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