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Structure paper

TitleDopamine reuptake and inhibitory mechanisms in human dopamine transporter
Journal, issue, pagesNature, Year 2024
Publish dateJan 25, 2024 (structure data deposition date)
AuthorsZhao Y / Li Y
External linksNature / Search PubMed
MethodsEM (single particle)
Resolution2.8 - 3.16 Å
Structure data

38850
EMDB entry, No image

8y2c

EMDB-38850, PDB-8y2c:
Cryo-EM structure of human dopamine transporter in apo state
Method: EM (single particle) / Resolution: 3.16 Å

38851
EMDB entry, No image

8y2d

EMDB-38851, PDB-8y2d:
Cryo-EM structure of human dopamine transporter in complex with dopamine
Method: EM (single particle) / Resolution: 2.8 Å

38852
EMDB entry, No image

8y2e

EMDB-38852, PDB-8y2e:
Cryo-EM structure of human dopamine transporter in complex with benztropine
Method: EM (single particle) / Resolution: 3.03 Å

38853
EMDB entry, No image

8y2f

EMDB-38853: structure of a proteinACryo-EM structure of human dopamine transporter in complex with GBR12909
PDB-8y2f: Cryo-EM structure of human dopamine transporter in complex with GBR12909
Method: EM (single particle) / Resolution: 2.97 Å

38854
EMDB entry, No image

8y2g

EMDB-38854, PDB-8y2g:
Cryo-EM structure of human dopamine transporter in complex with methylphenidate
Method: EM (single particle) / Resolution: 2.83 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-LDP:
L-DOPAMINE / medication*YM

ChemComp-NA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CXQ:
benztropine / medication, antipsychotic*YM

PDB-1d5s:
CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER

PDB-1d5u:
Unknown entry

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / human dopamine transporter in apo state / human dopamine transporter in complex with dopamine / human dopamine transporter in complex with benztropine / human dopamine transporter human dopamine transporter / human dopamine transporter in complex with methylphenidate

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