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Structure paper

TitleVX-680/MK-0457 binds also to human ABL1 with inactive DFG conformations.
Journal, issue, pagesTo Be Published
Publish dateMay 6, 2015 (structure data deposition date)
AuthorsKyomuhendo, P. / Narayanan, D. / Engh, R.A.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-4zog:
VX-680/MK-0457 binds to human ABL1 also in inactive DFG conformations.
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-VX6:
CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE / inhibitor*YM

ChemComp-MXE:
2-METHOXYETHANOL

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Kinase / ABL1 / DFG conformations

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