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Title | Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus |
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Journal, issue, pages | MEDCHEMCOMM, Vol. 2, Page 828-839, Year 2011 |
Publish date | May 18, 2011 (structure data deposition date) |
Authors | Pfefferkorn, J.A. / Guzman-Perez, A. / Oates, P.J. / Litchfield, J. / Aspnes, G. / Basak, A. / Benbow, J. / Berliner, M.A. / Bian, J. / Choi, C. ...Pfefferkorn, J.A. / Guzman-Perez, A. / Oates, P.J. / Litchfield, J. / Aspnes, G. / Basak, A. / Benbow, J. / Berliner, M.A. / Bian, J. / Choi, C. / Freeman-Cook, K. / Corbett, J.W. / Didiuk, M. / Dunetz, J.R. / Filipski, K.J. / Hungerford, W.M. / Jones, C.S. / Karki, K. / Ling, A. / Li, J.-C. / Patel, L. / Perreault, C. / Risley, H. / Saenz, J. / Song, W. / Tu, M. / Aiello, R. / Atkinson, K. / Barucci, N. / Beebe, D. / Bourassa, P. / Bourbounais, F. / Brodeur, A.M. / Burbey, R. / Chen, J. / D'Aquila, T. / Derksen, D.R. / Haddish-Berhane, N. / Huang, C. / Landro, J. / Lapworth, A.L. / MacDougall, M. / Perregaux, D. / Pettersen, J. / Robertson, A. / Tan, B. / Treadway, J.L. / Liu, S. / Qiu, X. / Knafels, J. / Ammirati, M. / Song, X. / DaSilva-Jardine, P. / Liras, S. / Sweet, L. / Rolph, T.P. |
External links | MEDCHEMCOMM / Search PubMed |
Methods | X-ray diffraction |
Resolution | 2.18 Å |
Structure data | PDB-3s41: |
Chemicals | ChemComp-GLC: ChemComp-NA: ChemComp-S41: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / DIABETES MELLITUS / DISEASE MUTATION / GLYCOLYSIS |