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Structure paper

TitleMolecular mechanism of co-transcriptional H3K36 methylation by SETD2
Journal, issue, pagesTo Be Published
Publish dateJul 3, 2025 (structure data deposition date)
AuthorsWalshe JL / Ochmann M / Neef U / Dybkov O / Dienemann C / Oberthuer C / Zheenbekova A / Urlaub H / Cramer P
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.58 - 6.72 Å
Structure data

54247

9rtn

EMDB-54247, PDB-9rtn:
State 2 MAP 2 SPT6 with SETD2
Method: EM (single particle) / Resolution: 3.82 Å

54399

9rzc

EMDB-54399, PDB-9rzc:
State 3 MAP 1 SETD2 bound to distal H3 of upstream nucleosome
Method: EM (single particle) / Resolution: 3.66 Å

54400

9rzd

EMDB-54400, PDB-9rzd:
State 3 MAP 2 SPT6 with SETD2
Method: EM (single particle) / Resolution: 3.69 Å

54425

9s0u

EMDB-54425, PDB-9s0u:
State 3 MAP 3 RNA Pol II activated elongation complex with SETD2 bound to distal upstream H3
Method: EM (single particle) / Resolution: 6.72 Å

EMDB-54538: State 1 MAP1 RNA Pol II activated elongation complex with SETD2 and upstream hexasome
Method: EM (single particle) / Resolution: 3.89 Å

EMDB-54541: State 1 MAP2 RNA Pol II activated elongation complex with SETD2 and upstream hexasome
Method: EM (single particle) / Resolution: 3.71 Å

EMDB-54542: State 1 MAP4 RNA Pol II activated elongation complex with SETD2 and upstream hexasome
Method: EM (single particle) / Resolution: 3.58 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
  • sus scrofa (pig)
  • synthetic construct (others)
KeywordsTRANSCRIPTION / RNA Pol II Activated elongation complex Co-transcriptional H3K36me3 SETD2

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