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Structure paper

TitleAssembly and activation of the death-inducing signaling complex
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 122, Year 2025
Publish dateFeb 10, 2025 (structure data deposition date)
AuthorsFosuah E / Shen Z / Xie J / Wang C / Lin Q / Fu TM
External linksProc. Natl. Acad. Sci. USA / Search PubMed
MethodsEM (single particle)
Resolution3.07 - 3.51 Å
Structure data

49159

9n94

EMDB-49159, PDB-9n94:
Cryo-EM structure of FADD_DED filament
Method: EM (single particle) / Resolution: 3.07 Å

49266

9ncq

EMDB-49266, PDB-9ncq:
Cryo-EM structure of Fas-FADD complex
Method: EM (single particle) / Resolution: 3.51 Å

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / FADD / Caspase / DISC / Apoptosis / Innate Immunity / Filament / Fas / CD94 / helical assembly

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