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TitleStructures of the Mutagenic Bypass of the Major Cisplatin-DNA Lesion by Human DNA Polymerase Beta Reveal Insights into Cisplatin-Induced Mutagenesis
Journal, issue, pagesTo Be Published
Publish dateAug 20, 2019 (structure data deposition date)
AuthorsOuzon-Shubeita, H. / Vilas, C.K. / Lee, S.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-6u2o:
Structure of human DNA polymerase beta misinserting dAMPNPP opposite the 5'G of the cisplatin Pt-GG intrastrand crosslink
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-DZ4:
2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine

ChemComp-CPT:
Cisplatin / medication, chemotherapy*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/DNA / polymerase / cisplatin / mismatch / Pt-GG / TRANSFERASE / TRANSFERASE-DNA complex

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