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TitleGeneration of AZD7789, a novel PD-1 and TIM-3 targeting bispecific antibody, which binds to a differentiated epitope of TIM-3
Journal, issue, pagesTo be published
Publish dateJun 28, 2023 (structure data deposition date)
AuthorsClancy-Thompson, E. / Perry, T. / Pryts, S. / Jaiswal, A. / Oganesyan, V. / van Dyk, N. / Yang, C. / Garcia, A. / Yu, W. / Moynihan, J. ...Clancy-Thompson, E. / Perry, T. / Pryts, S. / Jaiswal, A. / Oganesyan, V. / van Dyk, N. / Yang, C. / Garcia, A. / Yu, W. / Moynihan, J. / Miller, C. / Mulgrew, K. / Cobbold, M. / Mazor, Y. / Hammond, S. / Pollizzi, K.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.3 - 2.5 Å
Structure data

PDB-8tbb:
F9S, novel TIM-3 targeting antibody, bound to IgV domain of TIM-3
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-8tft:
Fab of O13-1 human IgG1 antibody bound to IgV domain of human TIM-3
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Fab / IgV domain of TIM-3 / complex / Fragment antigen binding / antibody / T-cell immunoglobulin mucin receptor 3 (TIM-3) / IgV type domain

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