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Structure paper

TitleHIF prolyl hydroxylase 2 (PHD2) T387V variant bound to Hypoxia-inducible Factor 2alpha (HIF-2alpha
Journal, issue, pagesTo Be Published
Publish dateJan 31, 2024 (structure data deposition date)
AuthorsFiorini, G. / Schofield, C.J.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.62 Å
Structure data

PDB-8rut:
HIF prolyl-hydroxylase-2 (PHD2) T387V variant bound to Fe(III), 2-oxoglutarate (2OG) and Hypoxia-inducible Factor-2alpha (HIF-2alpha)
Method: X-RAY DIFFRACTION / Resolution: 1.62 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-AKG:
2-OXOGLUTARIC ACID

ChemComp-FE:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / 2OG oxygenase / Oxygen sensing / Prolyl Hydroxylase / substrate complex

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