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TitleCryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 bound twice in the long-lived symmetric desensitised state
Journal, issue, pagesTo Be Published
Publish dateMay 23, 2024 (structure data deposition date)
AuthorsMihaylov DB / Malinauskas T / Aricescu AR
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.1 Å
Structure data

50383

9fg3

EMDB-50383, PDB-9fg3:
Cryo-EM structure of the alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Nb38 bound twice in the long-lived symmetric desensitised state
Method: EM (single particle) / Resolution: 3.1 Å

Chemicals

ChemComp-D10:
DECANE

ChemComp-D3D:
(19S,22R,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9E)-octadec-9-enoate

ChemComp-ABU:
GAMMA-AMINO-BUTANOIC ACID

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsMEMBRANE PROTEIN / GABA / neurotransmission / gating cycle / time-resolved cryo-EM

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