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TitleStructure based design of a positive allosteric modulator of mu-opioid receptor for synergistic analgesia
Journal, issue, pagesTo Be Published
Publish dateFeb 3, 2024 (structure data deposition date)
AuthorsLuo P / Xu Y / Wang Y / Zhuang Y / Xu HE
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.65 - 2.84 Å
Structure data

39010

8y72

EMDB-39010, PDB-8y72:
positive allosteric modulator(BMS986122)-bound mu-opioid receptor-Gi complex
Method: EM (single particle) / Resolution: 2.65 Å

39011

8y73

EMDB-39011, PDB-8y73:
positive allosteric modulator(MPAM-15)-bound mu-opioid receptor-Gi complex
Method: EM (single particle) / Resolution: 2.84 Å

Chemicals

ChemComp-CLR:
CHOLESTEROL


ChemComp, No image

ChemComp-VV9:
Unknown entry

PDB-1d6c:
Unknown entry

Source
  • homo sapiens (human)
  • rattus norvegicus (Norway rat)
  • bos taurus (domestic cattle)
  • synthetic construct (others)
KeywordsMEMBRANE PROTEIN / positive allosteric modulator / BMS986122 / mu-opioid receptor / allosteric agonism / allosteric opioid analgesics / MPAM-15

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