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-Structure paper
| Title | Design of Bicyclic Peptide Tandems Mimicking the Homodimeric GDF15 Protein to Inhibit GDF15–GFRaL–RET Complex Cell Signaling |
|---|---|
| Journal, issue, pages | J. Med. Chem., Year 2025 |
| Publish date | Jan 10, 2025 (structure data deposition date) |
 Authors | Noisier, A.F.M. / Sandmark, J. / Edfeldt, F. / Backmark, A. / Broddefalk, J. / Wandzik, J. / Jurva, U. / Ek, M. / Johansson, C.A. / Barlind, L. ...Noisier, A.F.M. / Sandmark, J. / Edfeldt, F. / Backmark, A. / Broddefalk, J. / Wandzik, J. / Jurva, U. / Ek, M. / Johansson, C.A. / Barlind, L. / Gunnarsson, J. / Bigalke, J.M. / Xue, Y. / Frolov, A.I. / Kankkonen, C. / Roth, R.G. / Fritsch, M. / Watcham, S. / van Rietschoten, K. / Mudd, G.E. / Harrison, H. / Chen, L. / Skynner, M.J. / Craik, D.J. / Chankeshwara, S.V. / Lemurell, M. |
 External links | J. Med. Chem. / Search PubMed |
| Methods | X-ray diffraction |
| Resolution | 1.9 Å |
| Structure data |  PDB-9hyt: |
| Chemicals |  ChemComp-SO4:  ChemComp-ACY:  ChemComp-29N:  ChemComp-HOH: |
| Source |
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 Keywords | SIGNALING PROTEIN / GFRaL / GFRalpha-like / GDF15 / RET / inhibitor |
homo sapiens (human)