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TitleEngineering an Alcohol Dehydrogenase from Kluyveromyces polyspora for Efficient Synthesis of Ibrutinib Intermediate
Journal, issue, pagesAdv. Synth. Catal., Year 2021
Publish dateMay 3, 2020 (structure data deposition date)
AuthorsWu, Y.F. / Zhou, J.Y. / Ni, J. / Zhu, C. / Sun, Z. / Xu, G.C. / Ni, Y.
External linksAdv. Synth. Catal. / Search PubMed
MethodsX-ray diffraction
Resolution1.75 Å
Structure data

PDB-7c1e:
Crystal structure of Kluyveromyces polyspora ADH (KpADH) mutant (Y127W)
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-HOH:
WATER

Source
  • vanderwaltozyma polyspora (strain atcc 22028 / dsm 70294) (fungus)
KeywordsOXIDOREDUCTASE / Alcohol dehydrogenase(KpADH-Y127W) / NADPH

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