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TitleDe novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells
Journal, issue, pagesScience, Year 2025
Publish dateMar 5, 2025 (structure data deposition date)
AuthorsJohansen KH / Wolff DS / Scapolo B / Fernandez-Quintero ML / Christensen CR / Loeffler JR / Rivera-de-Torre E / Overath MD / Munk KK / Morell O ...Johansen KH / Wolff DS / Scapolo B / Fernandez-Quintero ML / Christensen CR / Loeffler JR / Rivera-de-Torre E / Overath MD / Munk KK / Morell O / Viuff MC / Damm Englund AT / Due M / Forli S / Andersen EQ / Fernandes JS / Thumtecho S / Ward AB / Ormhoj M / Hadrup SR / Jenkins TP
External linksScience / Search PubMed
MethodsEM (single particle)
Resolution3.8 Å
Structure data

49573

9nnf

EMDB-49573, PDB-9nnf:
Cryo-EM structure of a de-novo designed binder NY1-B04 in complex with HLA-A*02:01 and NY-ESO-1-derived peptide SLLMWITQC
Method: EM (single particle) / Resolution: 3.8 Å

Source
  • Bacillus subtilis (bacteria)
  • synthetic construct (others)
  • homo sapiens (human)
  • escherichia coli (E. coli)
KeywordsIMMUNE SYSTEM / De novo-designed pMHC binders / HLA

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