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Structure paper

TitleStructural Insights into the Role of eIF3 in Translation Mediated by the HCV IRES
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Year 2025
Publish dateNov 13, 2024 (structure data deposition date)
AuthorsIwasaki W / Kashiwagi K / Sakamoto A / Nishimoto M / Takahashi M / Machida K / Imataka H / Matsumoto A / Shichino Y / Iwasaki S ...Iwasaki W / Kashiwagi K / Sakamoto A / Nishimoto M / Takahashi M / Machida K / Imataka H / Matsumoto A / Shichino Y / Iwasaki S / Imami K / Ito T
External linksProc. Natl. Acad. Sci. USA / Search PubMed
MethodsEM (single particle)
Resolution3.0 - 3.3 Å
Structure data

62386

9kkf

EMDB-62386, PDB-9kkf:
Structure of the human 40S ribosome complexed with HCV IRES and eIF3
Method: EM (single particle) / Resolution: 3.3 Å

62453

9kn5

EMDB-62453, PDB-9kn5:
Structure of the human 40S ribosome complexed with HCV IRES, eIF1A and eIF3
Method: EM (single particle) / Resolution: 3.2 Å

62454

9kn6

EMDB-62454, PDB-9kn6:
Structure of the HCV IRES-dependent pre-48S translation initiation complex with eIF1A, eIF5B, and eIF3
Method: EM (single particle) / Resolution: 3.3 Å

62535

9krp

EMDB-62535, PDB-9krp:
Structure of the HCV IRES-dependent 48S translation initiation complex with eIF5B and eIF3
Method: EM (single particle) / Resolution: 3.2 Å

62671

9kzu

EMDB-62671, PDB-9kzu:
Cryo-EM structure of the HCV IRES-dependently initiated CMV-stalled 80S ribosome (non-rotated state) in complexed with eIF3
Method: EM (single particle) / Resolution: 3.0 Å

62679

9kzx

EMDB-62679, PDB-9kzx:
Cryo-EM structure of the HCV IRES-dependently initiated CMV-stalled 80S ribosome (rotated state) in complexed with eIF3
Method: EM (single particle) / Resolution: 3.3 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

Source
  • homo sapiens (human)
  • hepacivirus hominis
KeywordsRIBOSOME / HCV IRES

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