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TitleCrystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand
Journal, issue, pagesTo be Published
Publish dateApr 2, 2014 (structure data deposition date)
AuthorsFilippakopoulos, P. / Picaud, S. / Felletar, I. / Martin, S. / Monteiro, O. / Fedorov, O. / Chaikuad, A. / Yue, W. / von Delft, F. / Arrowsmith, C.H. ...Filippakopoulos, P. / Picaud, S. / Felletar, I. / Martin, S. / Monteiro, O. / Fedorov, O. / Chaikuad, A. / Yue, W. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Knapp, S. / Structural Genomics Consortium (SGC)
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.78 - 1.83 Å
Structure data

PDB-4q0n:
Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand
Method: X-RAY DIFFRACTION / Resolution: 1.78 Å

PDB-4q0o:
Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand
Method: X-RAY DIFFRACTION / Resolution: 1.83 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-2XD:
(2E)-1-(2-hydroxyphenyl)-3-(2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)prop-2-en-1-one

ChemComp-HOH:
WATER

ChemComp-K:
Unknown entry

ChemComp-2XC:
(2E)-1-(2-hydroxyphenyl)-3-[(3R)-3-phenylpiperidin-1-yl]prop-2-en-1-one

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / PB1 / POLYBROMO 1 ISOFORM 1 / BAF180 / POLYBROMO-1D / PBRM1 / BRG1-ASSOCIATED FACTOR 180 / BROMODOMAIN / CHROMATIN REGULATOR / DNA-BINDING / NUCLEUS / TRANSCRIPTION REGULATION / STRUCTURAL GENOMICS CONSORTIUM / SGC

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