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TitleCrystal Structure of HIV-1 L76V Protease in Complex with the Protease Inhibitor Darunavir.
Journal, issue, pagesTo be Published
Publish dateSep 22, 2010 (structure data deposition date)
AuthorsSchiffer, C.A. / Nalivaika, E.A. / Bandaranayake, R.M.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.76 Å
Structure data

PDB-3oy4:
Crystal Structure of HIV-1 L76V Protease in Complex with the Protease Inhibitor Darunavir.
Method: X-RAY DIFFRACTION / Resolution: 1.76 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-ACT:
ACETATE ION

ChemComp-017:
(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE / medication, antiretroviral*YM

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus type 1
KeywordsHydrolase/Hydrolase Inhibitor / HIV-1 protease / inhibitor resistance / AIDS / Aspartyl protease / Hydrolase-Hydrolase Inhibitor complex

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