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Structure paper

TitleHigh-resolution structure of a replication-initiation like configuration of influenza polymerase active site visualises the essential role of a conserved dibasic motif in the PA subunit
Journal, issue, pagesBiorxiv, Year 2024
Publish dateApr 25, 2024 (structure data deposition date)
AuthorsCusack, S. / Drncova, P. / Krischuns, T. / Naffakh, N.
External linksBiorxiv / Search PubMed
MethodsX-ray diffraction
Resolution1.905 Å
Structure data

PDB-9f37:
Replication-like initiation state of influenza polymerase with GTP and CTP at respectively the -1 and +1 positions (strain A/little yellow-shouldered bat/Guatemala/060/2010/H17N10)
Method: X-RAY DIFFRACTION / Resolution: 1.905 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-CTP:
CYTIDINE-5'-TRIPHOSPHATE

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-MGT:
7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE

ChemComp-HOH:
WATER

Source
  • influenza a virus
KeywordsVIRAL PROTEIN / RNA-dependent RNA polymerase

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