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-Structure paper
Title | Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disruptors of GK-GKRP Binding. |
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Journal, issue, pages | To be Published |
Publish date | Mar 24, 2014 (structure data deposition date) |
Authors | Pennington, L.D. / Bartberger, M.D. / Croghan, M.D. / Andrews, K.L. / Ashton, K.S. / Bourbeau, M.P. / Chen, J. / Chmait, S. / Cupples, R. / Fotsch, C. |
External links | Search PubMed |
Methods | X-ray diffraction |
Resolution | 2.6 Å |
Structure data | PDB-4pxs: |
Chemicals | ChemComp-2Y6: ChemComp-S6P: ChemComp-IOD: ChemComp-GOL: ChemComp-SO4: ChemComp-HOH: |
Source |
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Keywords | transferase/transferase inhibitor / SIS domain containing protein / GKRP binds to and inhibits Glucokinase activity / Glucokinase / Liver / transferase-transferase inhibitor complex |