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Structure paper

TitleThe structural basis of altered gene specificity resulting from meganuclease and MegaTAL engineering
Journal, issue, pagesto be published
Publish dateSep 29, 2016 (structure data deposition date)
AuthorsWerther, R. / Hallinan, J.P. / Lambert, A. / Haven, K. / Jarjor, J. / Stoddard, B.L.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution3.106 Å
Structure data

PDB-5thg:
Engineered variant of I-OnuI meganuclease targeting the HIV CCR5 gene; harbors 43 point mutations relative to wild-type I-OnuI
Method: X-RAY DIFFRACTION / Resolution: 3.106 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
KeywordsHYDROLASE/DNA / Meganuclease / Engineered protein / DNA complex / HYDROLASE-DNA complex

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