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Structure paper

TitleDesign, Synthesis, and Bioevaluation of Pyrazolo[1,5-a]Pyrimidine Derivatives as Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site with Potent Anticancer Activities
Journal, issue, pagesTo Be Published
Publish dateJan 17, 2020 (structure data deposition date)
AuthorsGang, L. / Wang, Y.X. / Chen, J.J.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.445 - 2.751 Å
Structure data

PDB-6lsm:
Tubulin Polymerization Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.751 Å

PDB-6lsn:
Crystal structure of tubulin-inhibitor complex
Method: X-RAY DIFFRACTION / Resolution: 2.445 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-ERX:
2-(4-methylphenyl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-HOH:
WATER

ChemComp-ERR:
2-(1-methylindol-5-yl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine

Source
  • sus scrofa (pig)
  • mus musculus (house mouse)
  • gallus gallus (chicken)
KeywordsCELL CYCLE / tubulin complex / Inhibitor

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