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TitlePyridone Diaryl Ether Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase
Journal, issue, pagesTo be Published
Publish dateDec 3, 2008 (structure data deposition date)
AuthorsKennedy-Smith, J. / Sweeney, Z.K.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-3ffi:
HIV-1 RT with pyridone non-nucleoside inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-3OB:
3-chloro-5-({6-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-3-(dimethylamino)-2-oxo-1,2-dihydropyridin-4-yl}oxy)benzonitrile

ChemComp-HOH:
WATER

Source
  • hiv-1 m:b_hxb2r (virus)
KeywordsTRANSFERASE / HIV / RT / REVERSE TRANSCRIPTASE / TRANSFERASE RNA-DIRECTED DNA POLYMERASE / NUCLEOTIDYLTRANSFERASE / AIDS / Cytoplasm / Viral nucleoprotein / Hydrolase

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