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Structure paper

TitleCrystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target.
Journal, issue, pagesStructure, Vol. 6, Page 1587-1599, Year 1998
Publish dateNov 20, 1998 (structure data deposition date)
AuthorsSharma, V. / Grubmeyer, C. / Sacchettini, J.C.
External linksStructure / PubMed:9862811
MethodsX-ray diffraction
Resolution2.4 - 2.6 Å
Structure data

PDB-1qpn:
Quinolinate Phosphoribosyl Transferase from Mycobacterium Tuberculosis in Complex with NCNN
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-1qpo:
Quinolinate Phosphoribosyl Transferase (QAPRTase) Apo-Enzyme from Mycobacterium Tuberculosis
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-1qpq:
Structure of Quinolinic Acid Phosphoribosyltransferase from Mycobacterium Tuberculosis: A Potential TB Drug Target
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-1qpr:
QUINOLINATE PHOSPHORIBOSYLTRANSFERASE (QAPRTASE) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PHTHALATE AND PRPCP
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

Chemicals

ChemComp-NCN:
NICOTINATE MONONUCLEOTIDE

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-NTM:
QUINOLINIC ACID

ChemComp-MN:
Unknown entry

ChemComp-PHT:
PHTHALIC ACID

ChemComp-PPC:
1-O-[(R)-hydroxy(phosphonomethyl)phosphoryl]-5-O-phosphono-alpha-D-ribofuranose

Source
  • mycobacterium tuberculosis h37rv (bacteria)
KeywordsTRANSFERASE / TYPE II PRTASE / DE NOVO NAD BIOSYNTHESIS / PRPP / PHOSPHORIBOSYL TRANSFERASE / QUINOLINIC ACID / NAMN / Structural Genomics / PSI / Protein Structure Initiative / TB Structural Genomics Consortium / TBSGC / PRTASE / PHOSPHORIBOSYLTRANSFERASE

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