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TitleA single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase.
Journal, issue, pagesProtein Sci., Vol. 7, Page 2249-2255, Year 1998
Publish dateJun 8, 1998 (structure data deposition date)
AuthorsFox, T. / Coll, J.T. / Xie, X. / Ford, P.J. / Germann, U.A. / Porter, M.D. / Pazhanisamy, S. / Fleming, M.A. / Galullo, V. / Su, M.S. / Wilson, K.P.
External linksPubMed:9827991
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-1pme:
STRUCTURE OF PENTA MUTANT HUMAN ERK2 MAP KINASE COMPLEXED WITH A SPECIFIC INHIBITOR OF HUMAN P38 MAP KINASE
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-SB2:
4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / MAP KINASE / SERINE/THREONINE PROTEIN KINASE

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