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TitleCrystal structures of two tropinone reductases: different reaction stereospecificities in the same protein fold.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 95, Page 4876-4881, Year 1998
Publish dateOct 23, 1997 (structure data deposition date)
AuthorsNakajima, K. / Yamashita, A. / Akama, H. / Nakatsu, T. / Kato, H. / Hashimoto, T. / Oda, J. / Yamada, Y.
External linksProc. Natl. Acad. Sci. USA / PubMed:9560196
MethodsX-ray diffraction
Resolution2.3 - 2.4 Å
Structure data

PDB-1ae1:
TROPINONE REDUCTASE-I COMPLEX WITH NADP
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-2ae1:
TROPINONE REDUCTASE-II
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-HOH:
WATER

Source
  • datura stramonium (jimsonweed)
KeywordsOXIDOREDUCTASE / TROPANE ALKALOID BIOSYNTHESIS / REDUCTION OF TROPINONE TO TROPINE / SHORT-CHAIN DEHYDROGENASE / REDUCTION OF TROPINONE TO PSEUDOTROPINE

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