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TitleAntibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-beta-lactamase.
Journal, issue, pagesChem. Biol., Vol. 5, Page 185-196, Year 1998
Publish dateMar 23, 1998 (structure data deposition date)
AuthorsToney, J.H. / Fitzgerald, P.M. / Grover-Sharma, N. / Olson, S.H. / May, W.J. / Sundelof, J.G. / Vanderwall, D.E. / Cleary, K.A. / Grant, S.K. / Wu, J.K. ...Toney, J.H. / Fitzgerald, P.M. / Grover-Sharma, N. / Olson, S.H. / May, W.J. / Sundelof, J.G. / Vanderwall, D.E. / Cleary, K.A. / Grant, S.K. / Wu, J.K. / Kozarich, J.W. / Pompliano, D.L. / Hammond, G.G.
External linksChem. Biol. / PubMed:9545432
MethodsX-ray diffraction
Resolution2.55 Å
Structure data

PDB-1a8t:
METALLO-BETA-LACTAMASE IN COMPLEX WITH L-159,061
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-061:
2-BUTYL-6-HYDROXY-3-[2'-(1H-TETRAZOL-5-YL)-BIPHENYL-4-YLMETHYL]-3H-QUINAZOLIN-4-ONE

ChemComp-HOH:
WATER

Source
  • bacteroides fragilis (bacteria)
KeywordsHYDROLASE / BETA-LACTAMASE / METALLO-BETA-LACTAMASE / ZINC / ANTIBIOTIC RESISTANCE

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