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Structure paper

TitleStructural basis for specificity of retroviral proteases.
Journal, issue, pagesBiochemistry, Vol. 37, Page 4518-4526, Year 1998
Publish dateApr 16, 1998 (structure data deposition date)
AuthorsWu, J. / Adomat, J.M. / Ridky, T.W. / Louis, J.M. / Leis, J. / Harrison, R.W. / Weber, I.T.
External linksBiochemistry / PubMed:9521772
MethodsX-ray diffraction
Resolution2 - 2.4 Å
Structure data

PDB-1a94:
STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1bai:
Crystal structure of Rous sarcoma virus protease in complex with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-0Q4:
N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
  • rous sarcoma virus
KeywordsHYDROLASE/HYDROLASE INHIBITOR / HUMAN IMMUNODEFICIENCY VIRUS PROTEASE / ROUS SARCOMA VIRUS PROTEASE / PROTEIN-MEDIATED INTERACTION / VIRAL MATURATION / HYDROLASE-HYDROLASE INHIBITOR COMPLEX

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