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Structure paper

TitleCrystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu.
Journal, issue, pagesProtein Sci., Vol. 6, Page 2504-2511, Year 1997
Publish dateApr 23, 1997 (structure data deposition date)
AuthorsStrop, P. / Changchien, L. / Maley, F. / Montfort, W.R.
External linksPubMed:9416600
MethodsX-ray diffraction
Resolution2.2 - 2.4 Å
Structure data

PDB-1aiq:
CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE R126E MUTANT
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-1ajm:
CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE R126E MUTANT
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-UMP:
2'-DEOXYURIDINE 5'-MONOPHOSPHATE

ChemComp-CB3:
10-PROPARGYL-5,8-DIDEAZAFOLIC ACID

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
KeywordsTRANSFERASE / METHYLTRANSFERASE / DUMP

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