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TitleProtein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.
Journal, issue, pagesNat. Struct. Biol., Vol. 4, Page 796-801, Year 1997
Publish dateAug 5, 1997 (structure data deposition date)
AuthorsLawrie, A.M. / Noble, M.E. / Tunnah, P. / Brown, N.R. / Johnson, L.N. / Endicott, J.A.
External linksNat. Struct. Biol. / PubMed:9334743
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-1aq1:
HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-STU:
STAUROSPORINE / anticancer, antifungal, antibiotic, alkaloid*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN KINASE / CELL CYCLE / PHOSPHORYLATION / STAUROSPORINE / CELL DIVISION / MITOSIS / INHIBITION

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