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TitleStructural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors.
Journal, issue, pagesJ. Biol. Chem., Vol. 272, Page 21713-21719, Year 1997
Publish dateFeb 17, 1998 (structure data deposition date)
AuthorsRenatus, M. / Bode, W. / Huber, R. / Sturzebecher, J. / Prasa, D. / Fischer, S. / Kohnert, U. / Stubbs, M.T.
External linksJ. Biol. Chem. / PubMed:9268299
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-1a5h:
CATALYTIC DOMAIN OF HUMAN TWO-CHAIN TISSUE PLASMINOGEN ACTIVATOR COMPLEX OF A BIS-BENZAMIDINE
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-BBA:
2,7-BIS-(4-AMIDINOBENZYLIDENE)-CYCLOHEPTAN-1-ONE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / TRYPSIN LIKE SERINE PROTEASE / FIBRINOLYTIC ENZYME

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