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-Structure paper
Title | Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 94, Page 3984-3989, Year 1997 |
Publish date | Mar 17, 1997 (structure data deposition date) |
Authors | Esnouf, R.M. / Ren, J. / Hopkins, A.L. / Ross, C.K. / Jones, E.Y. / Stammers, D.K. / Stuart, D.I. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:9108091 |
Methods | X-ray diffraction |
Resolution | 2.65 Å |
Structure data | PDB-1klm: |
Chemicals | ChemComp-SPP: ChemComp-HOH: |
Source |
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Keywords | NUCLEOTIDYLTRANSFERASE / AIDS / HIV-1 / ENDONUCLEASE / RNA-DIRECTED DNA POLYMERASE / HIV-1 REVERSE TRANSCRIPTASE / BHAP U-90152 / DRUG |