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Structure paper

TitleCrystal structure of human osteoclast cathepsin K complex with E-64.
Journal, issue, pagesNat. Struct. Biol., Vol. 4, Page 109-111, Year 1997
Publish dateDec 19, 1996 (structure data deposition date)
AuthorsZhao, B. / Janson, C.A. / Amegadzie, B.Y. / D'Alessio, K. / Griffin, C. / Hanning, C.R. / Jones, C. / Kurdyla, J. / McQueney, M. / Qiu, X. ...Zhao, B. / Janson, C.A. / Amegadzie, B.Y. / D'Alessio, K. / Griffin, C. / Hanning, C.R. / Jones, C. / Kurdyla, J. / McQueney, M. / Qiu, X. / Smith, W.W. / Abdel-Meguid, S.S.
External linksNat. Struct. Biol. / PubMed:9033588
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-1atk:
CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH THE COVALENT INHIBITOR E-64
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-E64:
N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / SULFHYDRYL PROTEINASE

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