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TitleInhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine.
Journal, issue, pagesEur. J. Biochem., Vol. 243, Page 518-526, Year 1997
Publish dateJun 29, 2005 (structure data deposition date)
AuthorsDe Azevedo, W.F. / Leclerc, S. / Meijer, L. / Havlicek, L. / Strnad, M. / Kim, S.H.
External linksEur. J. Biochem. / PubMed:9030780
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-2a4l:
Human cyclin-dependent kinase 2 in complex with roscovitine
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-RRC:
R-ROSCOVITINE / inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / SERINE/THREONINE PROTEIN KINASE / ATP-BINDING / CELL CYCLE / CELL DIVISION / ROSCOVITINE / PHOSPHORYLATION

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