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TitleStructure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid.
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 85, Page 921-930, Year 1996
Publish dateAug 9, 2001 (structure data deposition date)
AuthorsSintchak, M.D. / Fleming, M.A. / Futer, O. / Raybuck, S.A. / Chambers, S.P. / Caron, P.R. / Murcko, M.A. / Wilson, K.P.
External linksCell(Cambridge,Mass. ) / PubMed:8681386
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-1jr1:
Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-K:
Unknown entry

ChemComp-IMP:
INOSINIC ACID

ChemComp-MOA:
MYCOPHENOLIC ACID / medication, immunosuppressant*YM

ChemComp-HOH:
WATER

Source
  • cricetulus griseus (Chinese hamster)
KeywordsOXIDOREDUCTASE / DEHYDROGENASE / IMPD / IMPDH / GUANINE NUCLEOTIDE SYNTHESIS / MYCOPHENOLIC ACID / MPA

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