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Structure paper

TitleStructural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode.
Journal, issue, pagesNat. Struct. Biol., Vol. 3, Page 586-589, Year 1996
Publish dateJun 6, 1996 (structure data deposition date)
AuthorsRahuel, J. / Gay, B. / Erdmann, D. / Strauss, A. / Garcia-Echeverria, C. / Furet, P. / Caravatti, G. / Fretz, H. / Schoepfer, J. / Grutter, M.G.
External linksNat. Struct. Biol. / PubMed:8673601
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-1tze:
SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR, GRB2 SH2 DOMAIN COMPLEXED WITH PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (KFPPYVNC-NH2)
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCOMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) / SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR BOUND PROTEIN 2 (GRB2) SRC HOMOLOGY 2 DOMAIN (SH2) / PHOSPHOTYROSYL HEPTAPEPTIC LIGAND / COMPLEX (SIGNAL TRANSDUCTION-PEPTIDE) / COMPLEX (SIGNAL TRANSDUCTION-PEPTIDE) complex

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