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TitleInhibition and catalytic mechanism of HIV-1 aspartic protease.
Journal, issue, pagesJ. Mol. Biol., Vol. 255, Page 321-346, Year 1996
Publish dateOct 9, 1995 (structure data deposition date)
AuthorsSilva, A.M. / Cachau, R.E. / Sham, H.L. / Erickson, J.W.
External linksJ. Mol. Biol. / PubMed:8551523
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-1dif:
HIV-1 PROTEASE IN COMPLEX WITH A DIFLUOROKETONE CONTAINING INHIBITOR A79285
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-BME:
BETA-MERCAPTOETHANOL

ChemComp-A85:
N-{1-BENZYL-2,2-DIFLUORO-3,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
KeywordsASPARTIC PROTEINASE

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